GRowth and LifeStyle (GRLS) Study
Related link: GRLS Study website http://www.grlsstudy.org
Exposures during puberty, when the breast is developing, may be critical for the future development and prevention of breast cancer. The GRLS Study is part of the Center for Nutrient-Gene Interactions (CNGI) in Cancer Prevention (www.uab.edu/cngi), located at the University of Alabama, Birmingham (UAB), with studies conducted by researchers at the Northern California Cancer Center and at UAB. CNGI is addressing questions of how certain plant food compounds (i.e., polyphenols) may beneficially affect breast development, gene expression, and ultimately breast cancer, in animals and humans.
The GRLS study, conducted in the Greater San Francisco Bay Area, will look at how certain aspects of diet (most particularly, soy foods), lifestyle, and normal genetic variation affect growth and development around puberty. The 230 girls (ages 10-13 when the study began) and their parents are participating in several interviews over the course of the two-year study and the girls are being asked to provide saliva, blood and urine specimens. By participating in this study, these young women are making an important contribution to our understanding of how, in the future, we may be able to prevent breast cancer and other diseases later in life.
NCCC Principal Investigator: Pamela L. Horn-Ross, Ph.D.
Collaborators at UAB: Stephen Barnes, Ph.D., Michael Crowley, Ph.D., Renee Desmond, Ph.D., Helen Kim, Ph.D.
Funding: National Cancer Institute (U54 CA100949) |
