Reliability of EBV detection in Hodgkin lymphoma
Epstein-Barr virus (EBV) is a very common virus that has been linked to some cases of Hodgkin lymphoma. In the last ten years, the virus has been detected in stored pathology materials using two laboratory methods that require subjective interpretation. This study is the first to examine the accuracy of interpreting results of these two methods. Several pathologists reinterpreted the results of these tests on Hodgkin lymphoma tumors, and agreement between their interpretations and the original interpretation was compared.
NCCC Principal Investigator: Sally L. Glaser, Ph.D.
Collaborators: Richard F. Ambinder, M.D., Ph.D., Johns Hopkins Medical School; Margaret L. Gulley, M.D., University of Texas San Antonio
Funding Source: National Cancer Institute
Publications:
Glaser SL, Gulley ML, Borowitz M, Craig F, Mann RB, Stewart SL, Shema SJ, Ambinder RF. Inter-and intra-observer reliability of Epstein-Barr virus detection in Hodgkin lymphoma using histochemical procedures. Leuk Lymph 2004; 45:489-97.
Gulley ML, Glaser SL, Craig FE, Borowitz MD, Mann RB, Shema SJ, Ambinder RF. Guidelines for interpreting EBER in situ hybridization and LMP1 immunohistochemical tests for detecting Epstein-Barr virus in Hodgkin's disease. Am J Clin Pathol 2002; 117:259-67.
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