Insulin resistance and risk of prostate cancer
Background: Prostate cancer is the most common cancer among males in the United States and in Canada, yet there are few known risk factors. Treatment options continue to expand; however, little exists in the way of primary prevention. Evaluation of hormones and other blood based measures in relation to risk of disease is important because these levels may be modifiable through diet and exercise, and could provide a practical strategy to reduce the risk of prostate cancer.
Methods: A cohort of over 1,000 men donated a blood sample from 1990-1992. This group of men consisted of white, African-American and Asian men and was contacted again in 2002 to determine if any men had been diagnosed with prostate cancer during the 10-12 year period. We measured IGF-1, IGFBP-3, testosterone, DHT, SHBG, insulin and C-peptide (a surrogate for insulin) levels in serum samples collected at least one year prior to a diagnosis of prostate cancer.
Results: Pending publication
Summary: Pending publication
Principal Investigator: Rick Gallagher, M.S., British Columbia Cancer Center
Collaborators: Ingrid Oakley-Girvan, Ph.D., M.P.H., NCCC; Alice S. Whittemore, Ph.D., Stanford University; Anna Wu, Ph.D., University of Southern California; Larry Kolonel, Ph.D., Tumor Registry in Hawaii
Funding Source: National Cancer Institute of Canada (NCIC), Canadian Prostate Cancer Research Institute
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