Epstein-Barr virus in Hodgkin lymphoma in women
Epstein-Barr virus (EBV) is a very common virus that has been linked to some cases of Hodgkin lymphoma. However, little is known about why the virus appears to be involved with this lymphoma in some patients but not others. As part of a population-based study of Hodgkin lymphoma in adult women in the Greater Bay Area, small samples of stored tumor tissues removed during surgery were obtained and tested for the presence of EBV. Information about reproductive and other lifestyle factors reported by the patients in interviews will be related to the presence or absence of EBV in the tumor to better understand how EBV is related to Hodgkin lymphoma development and prognosis.
NCCC Principal Investigator: Sally L. Glaser, Ph.D.
Collaborator: Richard F. Ambinder, M.D., Ph.D., Johns Hopkins Medical School
Funding Source: National Cancer Institute
Publications:
Glaser SL, Keegan THM, Clarke CA, Trinh MA, Dorfman RF, Mann RB, DiGiuseppe JA, Ambinder RF. Exposure to childhood infections and risk of EBV-defined Hodgkin's lymphoma in women. Int J Cancer 2005;
Glaser SL, Keegan THM, Clarke CA, Darrow L, Gomez SL, Dorfman RF, Mann RB, DiGiuseppe JA, Ambinder RF. Smoking and Hodgkin lymphoma risk in women. Cancer Causes Control 2004; 15:387-397.
Clarke CA, Glaser SL, Dorfman RF, Mann R, DiGiuseppe JA, Prehn AW, Ambinder RF. Epstein-Barr virus and survival after Hodgkin's disease in a population-based series of women. Cancer 2001; 91:1579-87. |
